NH2-O-C5-COOH hydrobromide

Names

[ Name ]:
NH2-O-C5-COOH hydrobromide

[Synonym ]:
6-Aminooxy-hexanoic acid hydrobromide
6-Aminooxy-hexanoic acid
Hexanoicacid,6-(aminooxy)-,hydrobromide (1:1)

Biological Activity

[Description]:

NH2-O-C5-COOH (hydrobromide) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Boiling Point ]:
349.5ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₄BrNO₃

[ Molecular Weight ]:
228.08400

[ Flash Point ]:
165.2ºC

[ Exact Mass ]:
227.01600

[ PSA ]:
72.55000

[ LogP ]:
2.18010

NH2-O-C5-COOH hydrobromide

Names

Biological Activity

Chemical & Physical Properties

Related Compounds