1,3-difluoro-2-propanol

Names

[ CAS No. ]:
453-13-4

[ Name ]:
1,3-difluoro-2-propanol

[Synonym ]:
EINECS 207-216-6
1,3-difluoropropan-2-ol
1,3-Difluoro-2-propanol
MFCD00000452

Chemical & Physical Properties

[ Density]:
1.24 g/mL at 25 °C(lit.)

[ Boiling Point ]:
54-55 °C34 mm Hg(lit.)

[ Molecular Formula ]:
C₃H₆F₂O

[ Molecular Weight ]:
96.07590

[ Flash Point ]:
108 °F

[ Exact Mass ]:
96.03870

[ PSA ]:
20.23000

[ LogP ]:
0.28630

[ Vapour Pressure ]:
68.5mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.373(lit.)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UB1770000

CHEMICAL NAME :: 2-Propanol, 1,3-difluoro-

CAS REGISTRY NUMBER :: 453-13-4

BEILSTEIN REFERENCE NO. :: 1732050

LAST UPDATED :: 199701

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C3-H6-F2-O

MOLECULAR WEIGHT :: 96.09

WISWESSER LINE NOTATION :: F1YQ1F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00467

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R10;R36/37/38

[ Safety Phrases ]:
S16-S26-S36

[ RIDADR ]:
UN 1987 3/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
UB1770000

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
2905590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905590090

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

The mode of toxic action of the pesticide gliftor: the metabolism of 1,3-difluoroacetone to (-)-erythro-fluorocitrate.

J. Biochem. Mol. Toxicol. 15(1) , 47-54, (2001)

The biochemical toxicology of 1,3-difluoroacetone, a known metabolite of the major ingredient of the pesticide Gliftor (1,3-difluoro-2-propanol), was investigated in vivo and in vitro. Rat kidney homo...

Haloalcohols deplete glutathione when incubated with fortified liver fractions.

Xenobiotica 29(5) , 533-45, (1999)

1. This study has examined the ability of dichloropropanols, haloalcohols and their putative metabolites to deplete glutathione when incubated with liver fractions obtained from untreated and differen...

The biochemical toxicology of 1,3-difluoro-2-propanol, the major ingredient of the pesticide gliftor: the potential of 4-methylpyrazole as an antidote.

J. Biochem. Mol. Toxicol. 12(1) , 41-52, (1998)

Administration to rats of 1,3-difluoro-2-propanol (100 mg kg-1 body weight), the major ingredient of the pesticide gliftor, resulted in accumulation of citrate in the kidney after a 3 hour lag phase. ...