NSC 15364

Names

[ Name ]:
NSC 15364

[Synonym ]:
1,3-Bis(p-aminophenyl)urea
N,N'-Bis(4-aminophenyl)urea
1,3-bis-(4-aminophenyl)urea
1,3-Bis(4-aminophenyl)urea
Urea, N,N'-bis(4-aminophenyl)-
4,4'-diaminodiphenylurea
Carbanilide,4'-diamino
NSC 15364

Biological Activity

[Description]:

NSC 15364 is an inhibitor of VDAC1 oligomerization and apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

[In Vitro]

Mitochondrial membrane protein voltage-dependent anion channel 1 (VDAC1) oligomerization represents a prime target for agents designed to modulate apoptosis[1].

[References]

[1]. Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
381.4±27.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₄N₄O

[ Molecular Weight ]:
242.277

[ Flash Point ]:
184.5±23.7 °C

[ Exact Mass ]:
242.116760

[ PSA ]:
93.17000

[ LogP ]:
-0.50

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.785

[ Storage condition ]:
-20℃

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%