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Cbz-NH-PEG3-CH2COOH

Names

[ CAS No. ]:
462100-05-6

[ Name ]:
Cbz-NH-PEG3-CH2COOH

[Synonym ]:
2,7,10,13-Tetraoxa-4-azapentadecan-15-oic acid, 3-oxo-1-phenyl-
3-Oxo-1-phenyl-2,7,10,13-tetraoxa-4-azapentadecan-15-oic acid

Biological Activity

[Description]:

Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
534.1±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H23NO7

[ Molecular Weight ]:
341.356

[ Flash Point ]:
276.8±30.1 °C

[ Exact Mass ]:
341.147461

[ PSA ]:
106.81000

[ LogP ]:
0.44

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.519

Related Compounds