Asiatic acid

Names

[ CAS No. ]:
464-92-6

[ Name ]:
Asiatic acid

[Synonym ]:
2,3,23-TRIHYDROXY-12-URSEN-28-OIC ACID
(2α,3β)-2,3,23-Trihydroxyurs-12-en-28-oic acid
Asiatic acid
Urs-12-en-28-oic acid, 2,3,23-trihydroxy-, (2α,3β)-
Asiantic acid
Asiaticacid
UNII-9PA5A687X5
MFCD00238541
Dammarolic acid
EINECS 482-720-9

Biological Activity

[Description]:

Asiatic acid, a pentacyclic triterpene found in Centella asiatica, induces apoptosis in melanoma cells. Asiatic acid can be used to treat skin cancer[1]. Asiatic acid also has anti-inflammatory activities[2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Inflammation/Immunology

[References]

[1]. Park BC, et al. Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 2005 Jan 31;218(1):81-90.

[2]. Huang SS, et al. Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice. Evid Based Complement Alternat Med. 2011;2011:895857.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
609.4±55.0 °C at 760 mmHg

[ Melting Point ]:
325-330 °C(lit.)

[ Molecular Formula ]:
C₃₀H₄₈O₅

[ Molecular Weight ]:
488.699

[ Flash Point ]:
336.4±28.0 °C

[ Exact Mass ]:
488.350189

[ PSA ]:
97.99000

[ LogP ]:
6.46

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.579

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Biopharmaceutical and pharmacokinetic characterization of asiatic acid in Centella asiatica as determined by a sensitive and robust HPLC-MS method.

J. Ethnopharmacol. 163 , 31-8, (2015)

Asiatic acid is one of the main components in the herb Centella asiatica, which is a well-known herbal medicine for its excellent pharmacological effects. To enhance the development potentials of asia...

Asiatic acid ameliorates dextran sulfate sodium-induced murine experimental colitis via suppressing mitochondria-mediated NLRP3 inflammasome activation.

Int. Immunopharmacol. 24(2) , 232-8, (2015)

In the present study, the effect of asiatic acid, a natural triterpenoid compound, on murine experimental colitis induced by dextran sulfate sodium (DSS) and its possible mechanism were examined in vi...

Effecting skin renewal: a multifaceted approach.

J. Cosmet. Dermatol. 10(2) , 126-30, (2011)

The skin undergoes intrinsic aging as a normal course, but exposure to ultraviolet (UV) light results in major cumulative damage that manifests as the typical aged photodamaged skin. UV irradiation pr...