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Rehmannic acid

Names

[ CAS No. ]:
467-81-2

[ Name ]:
Rehmannic acid

[Synonym ]:
(22β)-22-{[(2Z)-2-Methyl-2-butenoyl]oxy}-3-oxoolean-12-en-28-oic acid
Olean-12-en-28-oic acid, 22-[[(2Z)-2-methyl-1-oxo-2-buten-1-yl]oxy]-3-oxo-, (22β)-

Biological Activity

[Description]:

Rehmannic acid (lantadene A) is a compound isolated from Lantana camara. Rehmannic acid shows considerable in vitro antioxidant, free radical scavenging capacity activities in a dose dependant manner. Rehmannic acid is a promising candidate for use as an antioxidant and hepatoprotective agent[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Barton, D. H. R., et al. Triterpenoids. Part XXIII. The nature of lantadene A.

[2]. Grace-Lynn C, et al. In vitro antioxidant activity potential of lantadene A, a pentacyclic triterpenoid of Lantana plants. Molecules. 2012;17(9):11185-11198.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
626.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H52O5

[ Molecular Weight ]:
552.784

[ Flash Point ]:
187.9±25.0 °C

[ Exact Mass ]:
552.381470

[ PSA ]:
80.67000

[ LogP ]:
9.56

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.552

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RK0252000
CHEMICAL NAME :
Olean-12-en-28-oic acid, 22-beta-hydroxy-3-oxo-, 2-methylcrotonate, (Z)-
CAS REGISTRY NUMBER :
467-81-2
LAST UPDATED :
199012
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C35-H52-O5
MOLECULAR WEIGHT :
552.87
WISWESSER LINE NOTATION :
L F6 E6 B666 TV DUTJ A1 H1 H1 JOVY1&U2 KVQ N1 O1 S1 S1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - domestic
DOSE/DURATION :
65 mg/kg
TOXIC EFFECTS :
Behavioral - food intake (animal) Gastrointestinal - decreased motility or constipation Liver - jaundice, other or unclassified
REFERENCE :
AUVJA2 Australian Veterinary Journal. (Australian Veterinary Assoc., Executive Director, 134-136 Hampden Road, Artarmon, N.S.W., Australia) V.2- 1927- Volume(issue)/page/year: 53,230,1977

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds