N-Desmethylnefopam

Names

[ Name ]:
N-Desmethylnefopam

[Synonym ]:
desmethyl nefopam
nor-nefopam
1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-1-phenyl

Biological Activity

[Description]:

N-Desmethylnefopam is the main metabolite of Nefopam. N-Desmethylnefopam is a centrally-acting but non-opioid analgesic agent, for the relief of moderate to severe pain. Nefopam targets β-catenin protein level in mesenchymal cells in-vitro and in-vivo[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Mittur A. A Simultaneous Mixed-Effects Pharmacokinetic Model for Nefopam, N-desmethylnefopam, and Nefopam N-Oxide in Human Plasma and Urine. Eur J Drug Metab Pharmacokinet. 2018 Aug;43(4):391-404.

[2]. Kim KH, et al. Rediscovery of nefopam for the treatment of neuropathic pain. Korean J Pain. 2014 Apr;27(2):103-11.

[3]. Baht GS, et al. Pharmacologically targeting beta-catenin for NF1 associated deficiencies in fracture repair. Bone. 2017 May;98:31-36.

Chemical & Physical Properties

[ Density]:
1.073g/cm3

[ Boiling Point ]:
383.4ºC at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₇NO

[ Molecular Weight ]:
239.31200

[ Flash Point ]:
157.1ºC

[ Exact Mass ]:
239.13100

[ PSA ]:
21.26000

[ LogP ]:
3.22460

[ Index of Refraction ]:
1.563

N-Desmethylnefopam

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds