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Sandaracopimaric acid

Names

[ CAS No. ]:
471-74-9

[ Name ]:
Sandaracopimaric acid

[Synonym ]:
Pimara-8(14),15-dien-18-oic acid
(ent)-pimara-8(14),15-dien-19-oic acid
pimaradienoic acid
(-)-pimara-8(14),15-diene-19-oic acid
1-Phenanthrenecarboxylic acid, 7-ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-
7-Ethenyl-1,2,3,4,4a,4b,5,6,7,9,10,10a-dodecahydro-1,4a,7-trimethyl-1-phenanthrenecarboxylic Acid
13-Methyl-17-norabieta-8(14),15-diene-18-oic acid
(-)-pimara-8(14),15-dien-19-oic acid

Biological Activity

[Description]:

Sandaracopimaric acid is a diterpenoid with anti-inflammatory effect. Sandaracopimaric acid reduces the contraction of phenylephrine-induced pulmonary arteries with an EC50 of 43.93 μM[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Wenyan Gao, et al. Dehydroabietic acid isolated from Commiphora opobalsamum causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Molecules. 2014 Jun 23;19(6):8503-17.

[2]. Masao Takei, et al. Diterpenes drive Th1 polarization depending on IL-12. Int Immunopharmacol. 2008 Nov;8(11):1602-8.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
413.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H30O2

[ Molecular Weight ]:
302.451

[ Flash Point ]:
198.7±23.4 °C

[ Exact Mass ]:
302.224579

[ PSA ]:
37.30000

[ LogP ]:
6.60

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.538

Related Compounds