LEVOBUNOLOL

Names

[ Name ]:
LEVOBUNOLOL

[Synonym ]:
LEVOBUNOLOL
Betagan
Levobunololum
MFCD00864586
Akbeta
5-[(2S)-3-(tert-butylamino)-2-hydroxypropoxy]-3,4-dihydro-2H-naphthalen-1-one
UNII-G6317AOI7K

Biological Activity

[Description]:

Levobunolol (l-Bunolol) is a potent and nonselective β-adrenergic receptor antagonist. Levobunolol is an ocular hypotensive agent and lowers mean intraocular pressure (IOP). Levobunolol can be used for glaucoma and superior oblique myokymia (SOM) research[1][2][3].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

[Target]

β-adrenoceptor

[References]

[1]. Mohammadi M, et al. Injectable drug depot engineered to release multiple ophthalmic therapeutic agents with precise time profiles for postoperative treatment following ocular surgery. Acta Biomater. 2018 Jun;73:90-102.

[2]. Kumar, N, et al. Extended levobunolol release from Eudragit nanoparticle-laden contact lenses for glaucoma therapy. Futur J Pharm Sci 6, 109 (2020).

[3]. Zhang M, et al. Superior oblique myokymia treated with levobunolol. J AAPOS. 2018 Feb;22(1):67-69.e2.

Chemical & Physical Properties

[ Melting Point ]:
205 - 210ºC

[ Molecular Formula ]:
C₁₇H₂₅NO₃

[ Molecular Weight ]:
291.38500

[ Exact Mass ]:
291.18300

[ PSA ]:
58.56000

[ LogP ]:
2.72430

[ Storage condition ]:
-20?C Freezer, Under Inert Atmosphere

Safety Information

[ HS Code ]:
2922509090

Customs

[ HS Code ]: 2922509090

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%