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(3β,5α,6β)-Androstane-3,5,6-triol

Names

[ CAS No. ]:
4725-51-3

[ Name ]:
(3β,5α,6β)-Androstane-3,5,6-triol

[Synonym ]:
androstane-3β,5α,6β-triol
Androstane-3,5,6-triol, (3β,5α,6β)-
Androstan-3β,5α,6β-triol
5α-androstane-3β,5,6β-triol
(3β,5α,6β)-Androstane-3,5,6-triol

Biological Activity

[Description]:

5α-Androstane-3β,5,6β-triol is a neuroprotectant. 5α-Androstane-3β,5,6β-triol can remarkably reverse intracellular acidification and alleviate neuronal injury through the inhibition of AMPK signaling. 5α-Androstane-3β,5,6β-triol remarkably reduced the infarct volume and attenuated neurologic impairment in acute ischemic stroke models of middle cerebral artery occlusion in vivo[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> AMPK
Signaling Pathways >> PI3K/Akt/mTOR >> AMPK
Research Areas >> Neurological Disease

[Target]

AMPK[1]


[References]

[1]. Xue D, et al. TRIOL Inhibits Rapid Intracellular Acidification and Cerebral Ischemic Injury: The Role of Glutamate in Neuronal Metabolic Reprogramming. ACS Chem Neurosci. 2022 Jun 30.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
430.1±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H32O3

[ Molecular Weight ]:
308.456

[ Flash Point ]:
193.1±20.5 °C

[ Exact Mass ]:
308.235138

[ PSA ]:
60.69000

[ LogP ]:
3.88

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.580

Related Compounds