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Tolbutamide Sodium

Names

[ CAS No. ]:
473-41-6

[ Name ]:
Tolbutamide Sodium

[Synonym ]:
Orinase Diagnostic
Sodium tolbutamide
Sodium butamide
Urea,1-butyl-3-(p-tolylsulfonyl)-,sodium salt
TOLBUTAMIDE SODIUM
Sodium orinase
1-Butyl-3-(p-tolylsulfonyl)urea monosodium salt
Tolbutamide sodium salt
Tolbutamide sodium,sterile
p-Toluenosulfonylbutylomocznik,sol sodowa [Polish]

Biological Activity

[Description]:

Tolbutamide sodium is a potent and orally active antidiabetic agent. Tolbutamide sodium induces apoptosis in a Ca2+ dependent manner in pancreatic β-cells. Tolbutamide sodium has the potential for the research of non-insulin-dependent diabetes mellitus[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Metabolic Disease

[References]

[1]. Trube G, et al. Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells. Pflugers Arch. 1986 Nov;407(5):493-9.

[2]. Efanova IB, et al. Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration. J Biol Chem. 1998 Dec 11;273(50):33501-7.

Chemical & Physical Properties

[ Density]:
1.184g/cm3

[ Molecular Formula ]:
C12H18N2O3S

[ Molecular Weight ]:
270.34800

[ Exact Mass ]:
270.10400

[ PSA ]:
87.14000

[ LogP ]:
3.45910

[ Index of Refraction ]:
1.532

Related Compounds