Amino-PEG9-amine

Names

[ CAS No. ]:
474082-35-4

[ Name ]:
Amino-PEG9-amine

[Synonym ]:
3,6,9,12,15,18,21,24,27-Nonaoxanonacosane-1,29-diamine

Biological Activity

[Description]:

Amino-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₄₄N₂O₉

[ Molecular Weight ]:
456.571

[ Flash Point ]:
263.9±22.4 °C

[ Exact Mass ]:
456.304688

[ LogP ]:
-4.09

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.467

[ Storage condition ]:
2-8°C

Amino-PEG9-amine

Names

Biological Activity

Chemical & Physical Properties

Related Compounds