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Nogo-66(1-40)

Names

[ CAS No. ]:
475221-20-6

[ Name ]:
Nogo-66(1-40)

[Synonym ]:
m.w. 4625.11 c206h324n56o65
nogo extracellular peptide,1-40
arg-ile-tyr-lys-gly-val-ile-gln-ala-ile-gln-lys-ser-asp-glu-gly-his-pro-phe-arg-ala-tyr-leu-glu-ser-glu-val-ala-ile-ser-glu-glu-leu-val-gln-lys-tyr-ser-asn-ser-nh2
nep1-40
ac-riykgviqaiqksdeghpfraylesevaiseelvqkysns-nh2

Biological Activity

[Description]:

NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

NEP(1-40) (89 μg/kg, ip, 15 min and 19 h post-injury) administration further shifts distributions of microglia away from an injury-induced activated morphology towards greater proportions of rod and macrophage-like morphologies[1]. Animal Model: 74 male Sprague-Dawley rats (328-377 g)[1]. Dosage: 89 μg/kg (97.5% PBS and 2.5% DMSO). Administration: IP, 15 min and 19 h post-injury. Result: Reduced NgR function immediately post-injury. Increased number of amoeboid microglia/macrophages at 2 days post-injury

[References]

[1]. Jenna M Ziebell, et al. Nogo Presence Is Inversely Associated With Shifts in Cortical Microglial Morphology Following Experimental Diffuse Brain Injury. Neuroscience. 2017 Sep 17;359:209-223.

Chemical & Physical Properties

[ Molecular Formula ]:
C118H177N35O29S

[ Molecular Weight ]:
4625.11000

[ Exact Mass ]:
4622.38000

[ PSA ]:
1986.84000

[ LogP ]:
3.52320

Related Compounds