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3'-Hydroxypterostilbene

Names

[ CAS No. ]:
475231-21-1

[ Name ]:
3'-Hydroxypterostilbene

[Synonym ]:
1,2-Benzenediol, 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]-
4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]-1,2-benzenediol
4-[2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol
4-(2-(3,5-dimethoxyphenyl)ethenyl)-1,2-benzenediol
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol
4-[(E)-2-(3,5-Dimethoxyphenyl)vinyl]benzene-1,2-diol
(E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol

Biological Activity

[Description]:

3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 µM for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy

[Target]

Apoptosis[1] Autophagy[1]


[References]

[1]. Cheng TC, et al. Potent anti-cancer effect of 3'-hydroxypterostilbene in human colon xenograft tumors. PLoS One. 2014 Nov 12;9(11):e111814.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
469.7±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H16O4

[ Molecular Weight ]:
272.296

[ Flash Point ]:
237.8±28.7 °C

[ Exact Mass ]:
272.104858

[ PSA ]:
58.92000

[ LogP ]:
3.68

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
-20℃

Related Compounds