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Uridine,2'-bromo-2'-deoxy- (7CI,8CI,9CI)

Names

[ CAS No. ]:
4753-02-0

[ Name ]:
Uridine,2'-bromo-2'-deoxy- (7CI,8CI,9CI)

[Synonym ]:
21-Brom-21-desoxyuridin
2'-Bromo-2'-desoxyuridin
Uridine, 2'-bromo-2'-deoxy-
2'-Bromo-2'-deoxyuridine
2'-bromo-2'-deoxy-uridine
2'-Brom-2'-desoxy-uridin
1-Piperidino-2-brom-1-phenyl-aethan
2'-Brom-2'-deoxy-uridin

Biological Activity

[Description]:

2′-Bromo-2′-deoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C9H11BrN2O5

[ Molecular Weight ]:
307.10

[ Exact Mass ]:
305.985138

[ PSA ]:
104.55000

[ LogP ]:
-0.93

[ Index of Refraction ]:
1.642

Related Compounds