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(7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol

Names

[ CAS No. ]:
477-19-0

[ Name ]:
(7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol

[Synonym ]:
[2]Benzopyrano[3,4-g]indol-7-ol, 1,2,3,5,5a,7,11b,11c-octahydro-9,10-dimethoxy-1-methyl-, (5aR,7S,11bS,11cS)-
ycorenine
(7α)-9,10-Dimethoxy-1-methyllycorenan-7-ol

Biological Activity

[Description]:

Lycorenine is an alkaloid that has vasodepressor action. Lycorenine also exhibits anticancer and antibacterial activities[1][2][3].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Lycorenine inhibits the cell viability, with IC50s of 0.8 and 1.2 μg/mL for LMTK and HEPG2 cells, respectively[2].

[In Vivo]

Lycorenine (1-10 mg/kg i.v.) produces dose-related decreases in blood pressure and heart rate in anesthetized rats[1].

[References]

[1]. Miyasaka K, et, al. Pharmacological studies of lycorenine, an alkaloid of Lycoris radiata Herb.: Vasodepressor mechanism in rats. Jpn J Pharmacol. 1979 Aug;29(4):605-22.

[2]. Weniger B, et, al. Cytotoxic activity of Amaryllidaceae alkaloids. Planta Med. 1995 Feb;61(1):77-9.

[3]. Gu D, et, al. Antibacterial Phytosterols and Alkaloids from Lycoris radiate. Natural Product Sciences. 2014 Jou; 20(2): 107-112.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
477.7±45.0 °C at 760 mmHg

[ Melting Point ]:
199-200ºC

[ Molecular Formula ]:
C18H23NO4

[ Molecular Weight ]:
317.379

[ Flash Point ]:
242.7±28.7 °C

[ Exact Mass ]:
317.162720

[ PSA ]:
51.16000

[ LogP ]:
2.39

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.617

[ Storage condition ]:
2-8°C

Related Compounds