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meta-Fexofenadine

Names

[ CAS No. ]:
479035-75-1

[ Name ]:
meta-Fexofenadine

[Synonym ]:
Fexofenadine impurity B
2-[3-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid

Biological Activity

[Description]:

meta-Fexofenadine (meta-MDL-16455) is an impurity of Fexofenadine[1]. Fexofenadine, a H1R antagonist, is an anti-allergic agent used in seasonal allergic rhinitis and chronic idiopathic urticarial[2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[References]

[1]. Maher HM, et al. Development of validated stability-indicating chromatographic method for the determination of fexofenadine hydrochloride and its related impurities in pharmaceutical tablets. Chem Cent J. 2011 Dec 3;5(1):76.

[2]. Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75.

Chemical & Physical Properties

[ Molecular Formula ]:
C32H39NO4

[ Molecular Weight ]:
501.65600

[ Exact Mass ]:
501.28800

[ PSA ]:
81.00000

[ LogP ]:
5.44840

Related Compounds