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Amino-PEG11-amine

Names

[ CAS No. ]:
479200-82-3

[ Name ]:
Amino-PEG11-amine

[Synonym ]:
3,6,9,12,15,18,21,24,27,30,33-Undecaoxapentatriacontane-1,35-diamine

Biological Activity

[Description]:

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Shan M, et al. Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor. ACS Chem Biol. 2013 Apr 19;8(4):707-15.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
591.2±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H52N2O11

[ Molecular Weight ]:
544.677

[ Flash Point ]:
299.9±22.4 °C

[ Exact Mass ]:
544.357117

[ LogP ]:
-4.81

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.468

[ Storage condition ]:
2-8°C

Related Compounds