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NBQX disodium salt

Names

[ CAS No. ]:
479347-86-9

[ Name ]:
NBQX disodium salt

[Synonym ]:
Disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate
Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-, sodium salt (1:2)
FG9202 disodium
NBQX disodium
FG 9202 disodium salt hydrate
NBQX,Disodium Salt

Biological Activity

[Description]:

NBQX disodium (FG9202 disodium) is a highly selective and competitive AMPA receptor antagonist. NBQX disodium has neuroprotective and anticonvulsant activity[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

AMPA receptor[1]


[In Vitro]

NBQX disodium (FG9202 disodium) has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1].

[In Vivo]

NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) decreases seizures induced by PTZ[2]. NBQX disodium is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. Animal Model: Male Wistar rats that weighed 220-240 g with pentylenetetrazole (PTZ)[2] Dosage: 20 mg/kg Administration: IP; for 3 days Result: Effectively reversed the behavioral abnormality of epileptic seizures of chronic PTZ administration (50mg/kg; i.p.; for 28 days) in rats.

[References]

[1]. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014 Sep; 19(8):1174-84.

[2]. Wen Chen, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016 Nov 23;11(11):e0166672.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H6N4Na2O6S

[ Molecular Weight ]:
380.244

[ Exact Mass ]:
379.980347

[ PSA ]:
186.26000

[ LogP ]:
3.93050

Related Compounds