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eleutherol

Names

[ CAS No. ]:
480-00-2

[ Name ]:
eleutherol

[Synonym ]:
(R)-4-Hydroxy-5-methoxy-3-methyl-3H-naphtho[2,3-c]furan-1-one
(3R)-4-hydroxy-5-methoxy-3-methyl-3H-naphtho[2,3-c]furan-1-one
(3R)-4-Hydroxy-5-methoxy-3-methyl-3H-naphtho[2,3-c]furan-1-on

Biological Activity

[Description]:

Eleutherol is a naphthalene isolated from E. americana with antifungal activities[1]. Eleutherol is against yeasts Candida albicans, C. tropicalis, Saccharomyces cerevisiae and Cryptococcus neoformans with MIC values between 7.8 µg/mL and 250 µg/mL[1]. Eleutherol inhibits α-glucosidase function with an IC50>1.00 mM[2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> Fungal

[Target]

MIC: antifungal[1]


[References]

[1]. Adriana Campos, et al. Antifungal Activity of Pyranonaphthoquinones Obtained from Cipura paludosa Bulbs. Nat Prod Commun. 2015 Sep;10(9):1589-92.

[2]. Tomohiro Ieyama,et al.α-Glucosidase inhibitors from the bulb of Eleutherine americana. Food Chem.2011 Sep 15;128(2):308-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H12O4

[ Molecular Weight ]:
244.24300

[ Exact Mass ]:
244.07400

[ PSA ]:
55.76000

[ LogP ]:
2.78540

[ Storage condition ]:
-20°C

Related Compounds