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Lecanoricacid

Names

[ CAS No. ]:
480-56-8

[ Name ]:
Lecanoricacid

[Synonym ]:
Benzoic acid, 4-[(2,4-dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methyl-
4-[(2,4-Dihydroxy-6-methylbenzoyl)oxy]-2-hydroxy-6-methylbenzoic acid
4-(2,4-dihydroxy-6-methylbenzoyl)oxy-2-hydroxy-6-methylbenzoic acid
o-orsellinate depside
lecanoric aicd
Lecanoric acid
lecanolic acid
2,4-Dihydroxy-6-methylbenzoic acid 4-carboxy-3-hydroxy-5-methylphenyl ester
Lecanoricacid
Lecanorsaeure

Biological Activity

[Description]:

Lecanoric acid is a histidine-decarboxylase inhibitor isolated from fungus. The inhibition by lecanoric acid is competitive with histidineand noncompetitive with pyridoxal phosphate. Lecanoric acid did not inhibit aromatic amino acid decarboxylase[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others

[References]

[1]. Umezawa H, et al. Isolation of lecanoric acid, an inhibitor of histidine decarboxylase from a fungus. J Antibiot (Tokyo). 1974;27(8):587-596.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
557.1±50.0 °C at 760 mmHg

[ Melting Point ]:
175-176ºC

[ Molecular Formula ]:
C16H14O7

[ Molecular Weight ]:
318.278

[ Flash Point ]:
208.3±23.6 °C

[ Exact Mass ]:
318.073944

[ PSA ]:
124.29000

[ LogP ]:
4.39

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.675

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VH3709950
CHEMICAL NAME :
beta-Resorcylic acid, 6-methyl-, 4-(6-methyl-beta-resorcylate)
CAS REGISTRY NUMBER :
480-56-8
BEILSTEIN REFERENCE NO. :
2172778
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C16-H14-O7
MOLECULAR WEIGHT :
318.30
WISWESSER LINE NOTATION :
QVR BQ F1 DOVR DQ B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968- Volume(issue)/page/year: 27,587,1974

Safety Information

[ Hazard Codes ]:
Xi

Precursor & DownStream

Precursor

DownStream

Related Compounds