Integerrimine

Names

[ CAS No. ]:
480-79-5

[ Name ]:
Integerrimine

[Synonym ]:
Intergerrimine
senecionyne
Squalidine
INTEGERRIMINE
seneciionine
12-hydroxy-senecionane-11,16-dione

Biological Activity

[Description]:

(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[In Vitro]

(-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity[1].

[References]

[1]. V R Campesato, et al. Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster. Environ Mol Mutagen. 1997;29(1):91-7.

[2]. Walber Toma, et al. Modulation of gastrin and epidermal growth factor by pyrrolizidine alkaloids obtained from Senecio brasiliensis in acute and chronic induced gastric ulcers. Can J Physiol Pharmacol. 2004 May;82(5):319-25.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
563.7ºC at 760 mmHg

[ Melting Point ]:
172 °C

[ Molecular Formula ]:
C₁₈H₂₅NO₅

[ Molecular Weight ]:
335.39500

[ Flash Point ]:
294.7ºC

[ Exact Mass ]:
335.17300

[ PSA ]:
76.07000

[ LogP ]:
1.13070

[ Vapour Pressure ]:
4.68E-15mmHg at 25°C

[ Index of Refraction ]:
1.57

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM9080000

CHEMICAL NAME :: Integerrimine

CAS REGISTRY NUMBER :: 480-79-5

LAST UPDATED :: 199603

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 78 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg/20D-I

TOXIC EFFECTS :: Related to Chronic Data - death

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 18750 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 241,297,1990

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)