PAZ-417

Names

[ CAS No. ]:
481629-87-2

[ Name ]:
PAZ-417

[Synonym ]:
UNII-LL56J87F3X
Aleplasinin
PAZ-417

Biological Activity

[Description]:

Aleplasinin is an orally active, potent, BBB-penetrated and selectiveSERPINE1 (PAI-1, Plasminogen activator inhibitor-1) inhibitor. Aleplasinin increases amyloid-β (Aβ) catabolism and ameliorates amyloid-related pathology. Aleplasinin improves memory deficiency. Aleplasinin can be used for Alzheimer's disease research[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> PAI-1
Research Areas >> Neurological Disease

[References]

[1]. Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4.

[2]. Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.

Chemical & Physical Properties

[ Molecular Formula ]:
C28H27NO3

[ Molecular Weight ]:
425.51900

[ Exact Mass ]:
425.19900

[ PSA ]:
59.30000

[ LogP ]:
6.22980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds