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Saccharin 1-methylimidazole

Names

[ CAS No. ]:
482333-74-4

[ Name ]:
Saccharin 1-methylimidazole

[Synonym ]:
Saccharin 1-methylimidazole (SMI)
1-methyl-1H-imidazol-1-ium benzo[d]isothiazol-3-olate 1,1-dioxide

Biological Activity

[Description]:

Saccharin 1-methylimidazole is an activator for DNA/RNA Synthesis.

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Research Areas >> Cancer

[Target]

Target: DNA/RNA Synthesis[1]


[In Vitro]

Exposure to certain concentrations of the entirely different promoters phenobarbital and the calcium and sodium salts of saccharin (22, 23, 25, 29, 38) stimulates calcium-deprived T51B cells to initiate DNA synthesis as rapidly and as effectively, or nearly as effectively, as raising the extracellular calcium concentration to 1.25 mM[1].

[References]

[1]. Boynton AL, et al. Stimulation of DNA synthesis in calcium-deprived T51B liver cells by the tumor promoters phenobarbital, saccharin, and 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1980 Dec;40(12):4541-5.


[Related Small Molecules]

Cycloheximide | Actinomycin D | alpha-Amanitin | Anisomycin | SCR7 | CX-5461 | LMI070 | COH29 | Triciribine | Folic Acid | Halofuginone | RG7800 | ML216 | Adenine | Nedaplatin

Chemical & Physical Properties

[ Molecular Formula ]:
C11H11N3O3S

[ Molecular Weight ]:
265.29

[ PSA ]:
93.54000

[ LogP ]:
0.88720

[ Storage condition ]:
-20℃

Related Compounds