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Okanin

Names

[ CAS No. ]:
484-76-4

[ Name ]:
Okanin

[Synonym ]:
3,4,2',3',4'-Pentahydroxy-trans-chalkon
Okanin,2',3,3',4,4'-Pentahydroxychalcone
2',3,3',4,4'-Pentahydroxychalcone
OKANIN
(E)-3-(3,4-Dihydroxyphenyl)-1-(2,3,4-trihydroxyphenyl)-2-propen-1-one
2',3',4',3,4,-PENTAHYDROXYCHALCONE
2'.3'.4'.3.4-Pentahydroxy-chalkon
3,4,2',3',4'-pentahydroxy-trans-chalcone

Biological Activity

[Description]:

Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Research Areas >> Neurological Disease

[Target]

TLR4

p65


[In Vitro]

Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].

[References]

[1]. Hou Y, et al. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705.

Chemical & Physical Properties

[ Density]:
1.584g/cm3

[ Boiling Point ]:
638ºC at 760mmHg

[ Molecular Formula ]:
C15H12O6

[ Molecular Weight ]:
288.25

[ Flash Point ]:
353.7ºC

[ Exact Mass ]:
288.06300

[ PSA ]:
118.22000

[ LogP ]:
2.11070

[ Vapour Pressure ]:
7.12E-17mmHg at 25°C

[ Index of Refraction ]:
1.782

[ Storage condition ]:
-20 °C

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds