SNAP-94847 hydrochloride

Names

[ Name ]:
SNAP-94847 hydrochloride

[Synonym ]:
BW 723C86 hydrochloride

Biological Activity

[Description]:

SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCH1) antagonist with antidepressant-like activity, it differentiates from classic anxiolytic and antidepressant drugs.SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.SNAP 94847 is a high affinity antagonist (pA2 = 7.81) of MCH-evoked inositol phosphate formation[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24)

Research Areas >> Neurological Disease

[References]

[1]. David DJ, et al. Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis. J Pharmacol Exp Ther. 2007 Apr;321(1):237-48. Epub 2007 Jan 19.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₃ClF₂N₂O₂

[ Molecular Weight ]:
515.03400

[ Exact Mass ]:
514.22000

[ PSA ]:
45.06000

[ LogP ]:
8.42900

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS09

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H410

[ Precautionary Statements ]:
P273-P501

[ RIDADR ]:
UN 3077 9 / PGIII