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(N,N,O-2H3)Glycine

Names

[ CAS No. ]:
4896-76-8

[ Name ]:
(N,N,O-2H3)Glycine

[Synonym ]:
N,N,O-trideuterio-glycine
N,N,1-Trideutero-glycin
Glycine-N,N,1-d
glycine-N,N,O-d3
N,N,O-Trideuterio-glycin
N,N,O-d3-glycine
(N,N,O-H)Glycine
MFCD00074933

Biological Activity

[Description]:

Glycine-d3 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Cancer
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Johnson JW, et al. Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 1987 Feb 5-11;325(6104):529-31.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
240.9±23.0 °C at 760 mmHg

[ Melting Point ]:
240ºC (dec.)(lit.)

[ Molecular Formula ]:
C2H2D3NO2

[ Molecular Weight ]:
78.09

[ Flash Point ]:
99.5±22.6 °C

[ Exact Mass ]:
78.050858

[ PSA ]:
63.32000

[ LogP ]:
-1.03

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.461

MSDS

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Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds