2-Amino-6-methylthiopurine ribonucleoside

Names

[ Name ]:
2-Amino-6-methylthiopurine ribonucleoside

[Synonym ]:
S-methylthioguanosine
(2R,3R,4S,5R)-2-[2-amino-6-(methylthio)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
PC 250
S-methyl-6-thio-guanosine
HMS3078N18
6-(methylsulfanyl)-9-pentofuranosyl-9h-purin-2-amine

Biological Activity

[Description]:

2-Amino-6-meThythio-9-(β-D-ribofuranosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
1.98g/cm3

[ Boiling Point ]:
743.6ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₃N₅O₄S

[ Molecular Weight ]:
299.31

[ Flash Point ]:
403.5ºC

[ Exact Mass ]:
313.08400

[ PSA ]:
164.84000

[ Index of Refraction ]:
1.878

2-Amino-6-methylthiopurine ribonucleoside

Names

Biological Activity

Chemical & Physical Properties

Related Compounds