5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine

Names

[ Name ]:
5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine

[Synonym ]:
2-Thiazolamine, 5-ethyl-4-(4-methoxyphenyl)-
5-Ethyl-4-(4-methoxyphenyl)-1,3-thiazol-2-amine
thiazol-2-amine,17

Biological Activity

[Description]:

Runx1-CBFβ interaction inhibitor 1 is an allosteric inhibitior of Runt domain-CBFb interaction (IC50=3.2 μM)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Michael J Gorczynski, et al. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol. 2007 Oct;14(10):1186-97.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
421.5±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₄N₂OS

[ Molecular Weight ]:
234.317

[ Flash Point ]:
208.7±27.3 °C

[ Exact Mass ]:
234.082687

[ PSA ]:
76.38000

[ LogP ]:
2.94

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.606

Safety Information

[ HS Code ]:
2934100090

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%