7-Aminoclonazepam(CRM)

Names

[ Name ]:
7-Aminoclonazepam(CRM)

[Synonym ]:
2H-1,4-Benzodiazepin-2-one, 7-amino-5-(2-chlorophenyl)-1,3-dihydro-
3H-1,4-Benzodiazepin-2-ol, 7-amino-5-(2-chlorophenyl)-
7-Amino-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-amino-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-one

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
533.6±60.0 °C at 760 mmHg

[ Melting Point ]:
226-228ºC

[ Molecular Formula ]:
C₁₅H₁₂ClN₃O

[ Molecular Weight ]:
285.728

[ Flash Point ]:
276.5±32.9 °C

[ Exact Mass ]:
285.066895

[ PSA ]:
67.48000

[ LogP ]:
0.72

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.696

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H302 + H332-H319

[ Precautionary Statements ]:
P210-P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 1648 3 / PGII

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Extraction and analysis of clonazepam and 7-aminoclonazepam in whole blood using a dual internal standard methodology.

Forensic Sci. Int. 166(2-3) , 209-17, (2007)

In this paper, a simple and robust method for the determination of clonazepam and its primary metabolite (7-aminoclonazepam) in whole blood is described. Clonazepam (klonopin) is a popular prescriptio...

A highly sensitive method for the determination of 7-aminonitrazepam, a metabolite of nitrazepam, in human urine using high-performance electrospray liquid chromatography tandem mass spectrometry.

Biomed. Chromatogr. 23(7) , 740-4, (2009)

A highly sensitive method has been developed for the determination of urinary 7-aminonitrazepam (7-ANZP), the major metabolite of nitrazepam, using high-performance electrospray liquid chromatography ...

Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS.

Methods Mol. Biol. 603 , 107-19, (2010)

The benzodiazepines are a large, commonly prescribed family of psychoactive drugs. We describe a method permitting the simultaneous detection and quantification of 12 benzodiazepines in serum using ul...