TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE

Names

[ Name ]:
TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE

[Synonym ]:
TriethylenetetraMine Tetrahydrochloride
EINECS 225-604-3
N'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine,tetrahydrochloride
MFCD00012890

Chemical & Physical Properties

[ Density]:
1.49g/cm3

[ Boiling Point ]:
266.5ºC at 760 mmHg

[ Melting Point ]:
269-270 °C(lit.)

[ Molecular Formula ]:
C₆H₂₂Cl₄N₄

[ Molecular Weight ]:
292.07800

[ Flash Point ]:
143.3ºC

[ Exact Mass ]:
290.06000

[ PSA ]:
76.10000

[ LogP ]:
3.47340

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH8587087

CHEMICAL NAME :: 1,2-Ethanediamine, N,N'-bis(2-aminoethyl)-, tetrahydrochloride

CAS REGISTRY NUMBER :: 4961-40-4

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H18-N4.4Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2285 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - other changes Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),246,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970- Volume(issue)/page/year: 14,153,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 51390 mg/kg/90D-I

TOXIC EFFECTS :: Liver - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - changes in metals, not otherwise specified

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),246,1992

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H351

[ Precautionary Statements ]:
P261-P281-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S22-S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
KH8587087

[ HS Code ]:
2921290000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2921290000

[ Summary ]:
2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Apoptosis of acinar cells in the pancreas of rats fed on a copper-depleted diet.

Exp. Toxicol. Pathol. 45(8) , 489-95, (1994)

Male Fischer 344 rats weighing 80-90 g were fed on a copper-depleted diet supplemented with 0.6% triethylenetetramine tetrahydrochloride (a copper chelator), and the death of pancreatic acinar cells o...

Structural characteristics of low-molecular-mass displacers for cation-exchange chromatography: II. Role of the stationary phase. Shukla AA, et al.

J. Chromatogr. A. 872(2) , 295-310, (1998)