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TC-E 5008

Names

[ CAS No. ]:
50405-58-8

[ Name ]:
TC-E 5008

[Synonym ]:
6-benzyl-1-hydroxy-4-methylpyridin-2(1H)-one
6-Benzyl-1-hydroxy-4-methyl-2(1H)-pyridinone
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(phenylmethyl)-
SYC-435

Biological Activity

[Description]:

SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C; SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM).

[References]

References 1. Liu Z, et al. J Med Chem. 2014 Oct 23;57(20):8307-18. 2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159. View Related Products by Target Isocitrate Dehydrogenase (IDH)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
384.0±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H13NO2

[ Molecular Weight ]:
215.248

[ Flash Point ]:
186.0±25.9 °C

[ Exact Mass ]:
215.094635

[ LogP ]:
2.18

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.634

Related Compounds