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4,5-Dimethoxy-1,3,8-trihydroxyxanthone

Names

[ CAS No. ]:
5042-09-1

[ Name ]:
4,5-Dimethoxy-1,3,8-trihydroxyxanthone

[Synonym ]:
3,4-Dimethoxy-1,5,8-trihydroxy-xanthon
1,3,8-trihydroxy-4,5-dimethoxy-xanthen-9-one
1,3,8-Trihydroxy-4,5-dimethoxy-xanthen-9-on

Biological Activity

[Description]:

Corymbiferin is one of active constituents, responsible for anti-diabetic properties. Corymbiferin improves antioxidant capacity and carbohydrate metabolism in diabetic rats, along with the improvement of histopathology of livers and pancreatic β cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vivo]

The treatment with Corymbiferin (40 mg/kg; p.o.; male Wistar rats,) reduces the FBG level significantly, similar to the effect of positive metformin on the diabetic rats[1]. Corymbiferin (400 mg/kg; p.o.) also significantly reduces the blood glucose and shows a similar effect to metformin on oral glucose tolerance test (OGTT)[1].

[References]

[1]. Liu Z, et al. Hypoglycemic Activity and Antioxidative Stress of Extracts and Corymbiferin from Swertia bimaculata In Vitro and In Vivo. Evid Based Complement Alternat Med. 2013;2013:125416.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H12O7

[ Molecular Weight ]:
304.25200

[ Exact Mass ]:
304.05800

[ PSA ]:
109.36000

[ LogP ]:
2.08020

Related Compounds