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CP-9

Names

[ CAS No. ]:
505056-50-8

[ Name ]:
CP-9

[Synonym ]:
N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}acetamide
N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide
Acetamide, N-(5-methyl-3-isoxazolyl)-2-[[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-

Biological Activity

[Description]:

A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM); leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs); inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.

[References]

References 1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. View Related Products by Target Heat Shock Protein (HSP)

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
599.6±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C15H11F3N4O2S2

[ Molecular Weight ]:
400.399

[ Flash Point ]:
316.5±30.1 °C

[ Exact Mass ]:
400.027557

[ LogP ]:
3.42

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.618

Related Compounds