Aβ42 agonist-1

Names

[ Name ]:
Aβ42 agonist-1

[Synonym ]:
benzofuran-2-carboxylic acid anilide
Benzofuran-2-carbonsaeure-anilid

Biological Activity

[Description]:

Aβ42 agonist-1 (compound 7a) is a small molecule compound that can promote Aβ42 aggregation. Aβ42 agonist-1 can interact with Aβ42 oligomers and pentamers to promote nontoxic aggregate self-assembly and rapid fibril formation. Aβ42 agonist-1 prevents Aβ42-induced cytotoxicity in HT22 hippocampal neuronal cells[1].

[Related Catalog]:

Research Areas >> Neurological Disease

[Target]

Aβ42 aggregation[1]

[References]

[1]. Zhao Y et al. Small Molecules N-Phenylbenzofuran-2-carboxamide and N-Phenylbenzo[b]thiophene-2-carboxamide Promote Beta-Amyloid (Aβ42) Aggregation and Mitigate Neurotoxicity. ACS Chem Neurosci. 2023 Nov 16.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₁NO₂

[ Molecular Weight ]:
237.25300

[ Exact Mass ]:
237.07900

[ PSA ]:
42.24000

[ LogP ]:
3.75810

Aβ42 agonist-1

Names

Biological Activity

Chemical & Physical Properties

Precursor & DownStream

Precursor

DownStream

Related Compounds