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Tumulosic acid

Names

[ CAS No. ]:
508-24-7

[ Name ]:
Tumulosic acid

[Synonym ]:
3β,16α-dihydroxy-eburica-8,24(28)-dien-21-oic acid
3β,16α-Dihydroxy-eburica-8,24(28)-dien-21-saeure
3β.16α-Dihydroxy-24-methylen-lanosten-(8)-saeure-(21)
Tumulosaeure
Tumulossaeure

Biological Activity

[Description]:

Tumulosic acid, a triterpenoid, inhibits KLK5 protease activity (IC50= 14.84 μM). Tumulosic acid suppresses the proteolytic processing of LL-37 in keratinocytes at ≤10 μM[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vitro]

Tumulosic acid displays dose-dependent anti-KLK5 activity (IC50=19.3 μM)[1]. Tumulosic acid decreases in LL-37 production in human keratinocytes[1]. Tumulosic acid shows IC50 values of 14.84 and 10.48 μM against KLK5 and trypsin proteases, while it exhibited a weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0%, respectively, at 100 μM)[1]. Western Blot Analysis[1] Cell Line: Normal human epidermal keratinocytes (NHEKs) Concentration: 1 μM and 10 μM Incubation Time: 23 h in the presence of 10 μM cycloheximide Result: Decreased LL-37 production in epidermal keratinocytes.

[References]

[1]. Matsubara Y, et al. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22(11):1829. Published 2017 Oct 27.

Chemical & Physical Properties

[ Molecular Formula ]:
C31H50O4

[ Molecular Weight ]:
486.72600

[ Exact Mass ]:
486.37100

[ PSA ]:
77.76000

[ LogP ]:
6.76060

[ Storage condition ]:
2-8℃

Related Compounds