NH2-C2-NH-Boc-d4

Names

[ CAS No. ]:
509148-73-6

[ Name ]:
NH2-C2-NH-Boc-d4

[Synonym ]:
tert-Butyl [2-amino(H)ethyl]carbamate
Carbamic acid, N-(2-aminoethyl-1,1,2,2-d)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl [2-amino(H)ethyl]carbamate

Biological Activity

[Description]:

NH2-C2-NH-Boc-d4 is the deuterium labeled NH2-C2-NH-Boc[1]. NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.  

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
252.8±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C7H12D4N2O2

[ Molecular Weight ]:
164.239

[ Flash Point ]:
106.7±22.6 °C

[ Exact Mass ]:
164.146286

[ LogP ]:
0.54

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.454

Related Compounds