Phenelzine

Phenelzine is a non-selective and irreversible monoamine oxidase inhibitor (MAOI), used as an antidepressant and anxiolytic.

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Neurological Disease

Phenelzine (sulfate) | trans-2-Phenylcyclopropylamine hemisulfate salt | Clorgyline hydrochloride | Rosmarinic acid | pargyline hydrochloride | GSK-LSD1 Dihydrochloride | Rasagiline mesylate | Mofegiline hydrochloride | Paeonol | Iproniazid (phosphate) | Safinamide | TVP1022 | Minaprine | Nialamide | Desmethoxyyangonin

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C8-H12-N2

MOLECULAR WEIGHT :

136.22

WISWESSER LINE NOTATION :

ZM2R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

39600 ug/kg/44D-I

TOXIC EFFECTS :

Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis Behavioral - muscle contraction or spasticity

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - child

DOSE/DURATION :

7500 ug/kg

TOXIC EFFECTS :

Behavioral - ataxia Behavioral - somnolence (general depressed activity)

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Human - woman

DOSE/DURATION :

30 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema Liver - fatty liver degeneration

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

130 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

135 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

122 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

450 mg/kg

SEX/DURATION :

male 4 day(s) pre-mating female 4 day(s) pre-mating - 10 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

175 mg/kg

SEX/DURATION :

female 16-22 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Newborn - stillbirth Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

250 mg/kg

SEX/DURATION :

female 7-16 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

200 mg/kg

SEX/DURATION :

female 10-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

38800 ug/kg/24H

REFERENCE :

IMSCE2 IRCS Medical Science. (Lancaster, UK) V.12-14, 1984-86. For publisher information, see MSCREJ. Volume(issue)/page/year: 14,1052,1986