ATC 0175 hydrochloride

Names

[ Name ]:
ATC 0175 hydrochloride

[Synonym ]:
ATC0175
N-(cis-4-{[4-(Dimethylamino)quinazolin-2-yl]amino}cyclohexyl)-3,4-difluorobenzamide HCl

Biological Activity

[Description]:

ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> MCHR1 (GPR24)

Research Areas >> Neurological Disease

[Target]

IC50: 13.5 nM (MCH1R); >10000 nM (MCH2R)[1].

[In Vitro]

ATC0175 shows affinity for 5-HT2B and 5-HT1A with IC50s of 9.66 and 16.9 nM respectively[1].

[In Vivo]

ATC0175 (1, 3, 10 mg/kg; p.o.) significantly and dose-dependently reduces immobility time, indicating antidepressant like potential[1].

[References]

[1]. Chaki S, Yamaguchi J, Yamada H, Thomsen W, Tran TA, Semple G, Sekiguchi Y. ATC0175: an orally active melanin-concentrating hormone receptor 1 antagonist for the potential treatment of depression and anxiety. CNS Drug Rev. 2005 Winter;11(4):341-52.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₂₆ClF₂N₅O

[ Molecular Weight ]:
461.93500

[ Exact Mass ]:
461.17900

[ PSA ]:
70.15000

[ LogP ]:
5.39300

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335-H413

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

Articles

Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists.

J. Pharmacol. Exp. Ther. 313 , 831-839, (2005)

Melanin-concentrating hormone (MCH) is a cyclic peptide produced in the lateral hypothalamus. It has been implicated in a number of physiological processes including feeding behavior, energy balance, ...