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Substance P (5-11) trifluoroacetate salt

Names

[ CAS No. ]:
51165-09-4

[ Name ]:
Substance P (5-11) trifluoroacetate salt

[Synonym ]:
L-Gln-L-Gln-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
L-Glu(NH2)-L-Glu(NH2)-L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
H-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2
HEPTA-SUBSTANCE P
Substance-P-(5-11) Hepta-Substance P
substance P fragment 5-11
substance P5-11

Biological Activity

[Description]:

Substance P (5-11), the C-terminal heptapeptide of Substance P (Substance P (HY-P0201)), is a neuropeptide. Substance P (5-11) binds to NK-1 tachykinin receptor[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[In Vitro]

当将富含神经胶质细胞的兔脑部分与 [3H]Substance P (5-11) 一起孵育时，观察到 [3H]Substance P (5-11) 的摄取。当 Substance P 从神经末梢释放时，它被水解成 Substance P (5-11)，后者又积聚到神经胶质细胞和神经末梢，这种高亲和力摄取机制可能在终止突触过程中发挥重要作用[1]。

[References]

[1]. A Inoue, et al. Active uptake system for substance P carboxy-terminal heptapeptide (5-11) into a fraction from rabbit enriched in glial cells. Jpn J Pharmacol. 1984 Oct;36(2):137-45.  

Chemical & Physical Properties

[ Density]:
1.265g/cm3

[ Boiling Point ]:
1375.5ºC at 760 mmHg

[ Molecular Formula ]:
C41H60N10O9S

[ Molecular Weight ]:
869.04200

[ Flash Point ]:
785.6ºC

[ Exact Mass ]:
868.42700

[ PSA ]:
355.19000

[ LogP ]:
3.30140

[ Index of Refraction ]:
1.581

Synthetic Route

Click to get detail synthetic route

Related Compounds