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Guanosine,2'-deoxy-1-methyl-

Names

[ CAS No. ]:
5132-79-6

[ Name ]:
Guanosine,2'-deoxy-1-methyl-

[Synonym ]:
2'-deoxy-1-methylguanosine
2-Amino-3-methyl-3H-imidazole-4-carboxylic acid ethyl ester
1-N-methyl-2-amino imidazole-5-carboxylic acid ethyl ester
1-methyl-2'-deoxy-guanosine
2-Amino-5-carbethoxy-1-methyl-imidazol
1-Methyl-2-amino-5-carbethoxyimidazol
ethyl 2-amino-1-methyl-1H-imidazole-5-carboxylate
1-N-methyl-2'-deoxyguanosine
1-methyldeoxyguanosine

Biological Activity

[Description]:

2’-Deoxy-N1-methylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.88g/cm3

[ Boiling Point ]:
690.7ºC at 760mmHg

[ Molecular Formula ]:
C11H15N5O4

[ Molecular Weight ]:
281.27

[ Flash Point ]:
371.5ºC

[ Exact Mass ]:
281.11200

[ PSA ]:
128.42000

[ Index of Refraction ]:
1.823

[ Storage condition ]:
2-8°C

Related Compounds