COG 133

Names

[ Name ]:
COG 133

Biological Activity

[Description]:

COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor, with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

IC50: 445 nM (nAChR)[2]

[References]

[1]. Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35.

[2]. Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316(2):835-42.

Chemical & Physical Properties

[ Molecular Formula ]:
C₉₇H₁₈₁N₃₇O₁₉

[ Molecular Weight ]:
2169.71000

[ Exact Mass ]:
2168.43000

[ PSA ]:
948.24000

[ LogP ]:
7.91900

COG 133

Names

Biological Activity

Chemical & Physical Properties

MSDS

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Related Compounds