[1,1'-Biphenyl]-4-acetamide,N-2-pyridinyl-

Names

[ Name ]:
[1,1'-Biphenyl]-4-acetamide,N-2-pyridinyl-

[Synonym ]:
Z-876
2-Biphenylyl-N-pyridylacetamide
2-(4-phenylphenyl)-N-pyridin-2-ylacetamide
Pyridyl-biphenylyl-acetamide
Difenax
Acetamide,2-biphenylyl-N-pyridyl
Difenpiramide
Diphenpyramide

Biological Activity

[Description]:

Difenpiramide (Z-876) is a bisphenylalcanoic derivative with marked anti-inflammatory, analgesic, antipyretic and uricosuric properties. Difenpiramide has platelet anti-aggregation activity[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[References]

[1]. Caliari S, et al. Pharmacological properties of the anti-inflammatory agent pyridyl-biphenylyl-acetamide (diphenpyramide). Arzneimittelforschung. 1977;27(11):2086-2093.

[2]. Gugliotta L, et al. Farmaci antiinfiammatori e attività antiaggregante piastrinica: la difenpiramide [Anti-inflammatory drugs and platelet anti-aggregation activity: difenpiramide]. G Clin Med. 1976;57(11-12):408-415.

Chemical & Physical Properties

[ Density]:
1.192g/cm3

[ Boiling Point ]:
549ºC at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₆N₂O

[ Molecular Weight ]:
288.34300

[ Flash Point ]:
285.8ºC

[ Exact Mass ]:
288.12600

[ PSA ]:
41.99000

[ LogP ]:
4.00280

[ Index of Refraction ]:
1.645

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AB4549000

CHEMICAL NAME :: Acetamide, 2-biphenylyl-N-pyridyl-

CAS REGISTRY NUMBER :: 51484-40-3

BEILSTEIN REFERENCE NO. :: 0483768

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C19-H16-N2-O

MOLECULAR WEIGHT :: 288.37

WISWESSER LINE NOTATION :: T6NJ BMV1R DR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1857 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1396 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2590 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1471 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,2086,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 4 gm/kg

TOXIC EFFECTS :: Behavioral - analgesia Nutritional and Gross Metabolic - body temperature decrease Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 118,729,1979

Safety Information

[ HS Code ]:
2933399090

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%