sulfisomidine

Names

[ CAS No. ]:
515-64-0

[ Name ]:
sulfisomidine

[Synonym ]:
Solfisomidina
4-amino-N-(2,6-dimethyl-pyrimidin-4-yl)-benzenesulfonamide
Sulfaisodimidinum
4-amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
Sulfaisodimidine
Sulfisomidin
Sulfaisomidine
6-(Sulfanilamido)-2,4-dimethyl-1,3-diazine
sulfisomidine
Sulfadimetine
benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
Sulfuisodimidine
Sulphasomidine
Sulfasomidine
MFCD00010567
4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
Sulfudimetine
EINECS 208-204-3
Sulfamethin
2,6-dimethyl-4-pyrimidinyl sulphanilamide
6-(p-Aminophenylsulfonamido)-2,4-dimethylpyrimidine
Domain

Biological Activity

[Description]:

Sulfisomidin is a sulfonamide antibacterial.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[In Vitro]

Sulfisomidin (Sulfaisodimidine) is a short-acting antibacterial agent[1].

[References]

[1]. Bridges JW, et al. Species differences in the metabolism and excretion of sulphasomidine andsulphamethomidine. Biochem J. 1969 Jan;111(2):173-9.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
480.7±55.0 °C at 760 mmHg

[ Melting Point ]:
245ºC

[ Molecular Formula ]:
C₁₂H₁₄N₄O₂S

[ Molecular Weight ]:
278.330

[ Flash Point ]:
244.5±31.5 °C

[ Exact Mass ]:
278.083740

[ PSA ]:
106.35000

[ LogP ]:
-0.43

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9270000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(2,6-dimethyl-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 515-64-0

BEILSTEIN REFERENCE NO. :: 0261305

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-N4-O2-S

MOLECULAR WEIGHT :: 278.36

WISWESSER LINE NOTATION :: T6N CNJ B1 D1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 2500 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
UN 3249

[ RTECS ]:
WO9270000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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Coulometric determination of sulphisomidine, sulphamethoxydiazine and sulphamoxole.

J. Pharm. Biomed. Anal. 9(2) , 199-201, (1991)