DMH4

Names

[ Name ]:
DMH4

[Synonym ]:
6-{4-[2-(4-Morpholinyl)ethoxy]phenyl}-3-phenylpyrazolo[1,5-a]pyrimidine
Pyrazolo[1,5-a]pyrimidine, 6-[4-[2-(4-morpholinyl)ethoxy]phenyl]-3-phenyl-
dmh4
6-{4-[2-(morpholin-4-yl)ethoxy]phenyl}-3-phenylpyrazolo[1,5-a]pyrimidine

Biological Activity

[Description]:

DMH4 is a potent and selective inhibitor of VEGFR2 with an IC50 of 0.16 µM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR2:0.16 μM (IC50)

[References]

[1]. Hao J, et al. In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. ACS Chem Biol. 2010 Feb 19;5(2):245-53.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₂₄H₂₄N₄O₂

[ Molecular Weight ]:
400.473

[ Exact Mass ]:
400.189911

[ PSA ]:
51.89000

[ LogP ]:
2.12

[ Index of Refraction ]:
1.653

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ RIDADR ]:
NONH for all modes of transport

Articles

Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling.

Biochim. Biophys. Acta 1853(5) , 1154-64, (2015)

We previously identified peptide Lv, a novel bioactive peptide that enhances the activity of L-type voltage-gated calcium channels (L-VGCCs) in cone photoreceptors. In this study, we verified that pep...