ESI 05

Names

[ Name ]:
ESI 05

[Synonym ]:
mesityl(4-methylphenyl) sulfone

Biological Activity

[Description]:

ESI-05 (NSC 116966) is a specific exchange protein directly activated by cAMP 2 (EPAC2) antagonist (IC50, 0.4 µM), suppresses the cAMP-mediated activation of EPAC2 and inhibits Rap1 activation mediated by EAPC2[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[Target]

IC50: 0.4 µM (EPAC2)[1]

[References]

[1]. Tsalkova T, et al. Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18613-8.

Chemical & Physical Properties

[ Density]:
1.129g/cm3

[ Boiling Point ]:
426.7ºC at 760mmHg

[ Molecular Formula ]:
C₁₆H₁₈O₂S

[ Molecular Weight ]:
274.37800

[ Flash Point ]:
250ºC

[ Exact Mass ]:
274.10300

[ PSA ]:
42.52000

[ LogP ]:
4.83380

[ Index of Refraction ]:
1.562

ESI 05

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds