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D(-)-Amethopterin

Names

[ CAS No. ]:
51865-79-3

[ Name ]:
D(-)-Amethopterin

[Synonym ]:
DL-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
DL-Amethopterin
N-(4-{[(2,4-Diamino-6-pteridinyl)methyl](methyl)amino}benzoyl)glutamic acid
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
d-methotrexate
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-DL-glutamic acid
DL-Methotrexate
DL-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
DL-4-Amino-N10-methylpteroylglutamic acid
TCMDC-123832
Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-
UNII:99ITO15X8S
Einecs 257-482-2
N-(4-{[(2,4-Diaminopteridin-6-yl)methyl](methyl)amino}benzoyl)glutamic acid
D(-)-Amethopterin
Methotrexate Impurity 6

Chemical & Physical Properties

[ Density]:
1.537g/cm3

[ Melting Point ]:
195ºC

[ Molecular Formula ]:
C20H22N8O5

[ Molecular Weight ]:
454.439

[ Exact Mass ]:
454.171326

[ PSA ]:
210.54000

[ LogP ]:
-0.24

[ Index of Refraction ]:
1.738

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA1224000
CHEMICAL NAME :
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)b enzoyl)-, D-
CAS REGISTRY NUMBER :
51865-79-3
LAST UPDATED :
199610
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H22-N8-O5
MOLECULAR WEIGHT :
454.50
WISWESSER LINE NOTATION :
T66 BN DN GN JNJ CZ EZ H1N1&R DVMYVQ2VQ -D

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957- Volume(issue)/page/year: 29,43,1982

Safety Information

[ Risk Phrases ]:
61-46-25-36/37/38-60-23/24/25

[ Safety Phrases ]:
53-45-28A-36/37/39-26-22

[ RIDADR ]:
UN 1544 6.1/PG 3

[ HS Code ]:
29335995

Customs

[ HS Code ]: 29335995


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