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CJ 033466

Names

[ CAS No. ]:
519148-48-2

[ Name ]:
CJ 033466

[Synonym ]:
UNII-9KUW8W70PJ
CJ-033,466
PG-9 maleate

Biological Activity

[Description]:

CJ033466 is a novel and selective 5-HT4 receptor partial agonist with an EC50 of 9 nM and has gastroprokinetic effect[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT4 Receptor:9 nM (EC50)


[References]

[1]. Tadayoshi Mikami, et al. 5-Amino-6-chloro-N-[(1-isobutylpiperidin-4-yl)methyl]-2-methylimidazo[1,2-alpha]pyridine-8-carboxamide (CJ-033,466), a novel and selective 5-hydroxytryptamine4 receptor partial agonist: pharmacological profile in vitro and gastroprokinetic effect in conscious dogs. J Pharmacol Exp Ther. 2008 Apr;325(1):190-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H28ClN5O

[ Molecular Weight ]:
377.91200

[ Exact Mass ]:
377.19800

[ PSA ]:
75.66000

[ LogP ]:
3.88610

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds