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MCP110

Names

[ CAS No. ]:
521310-51-0

[ Name ]:
MCP110

[Synonym ]:
Benzenepentanamide, N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-N-[2-(2-pyridinyl)ethyl]-
N-[4-(benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(pyridin-2-yl)ethyl]pentanamide
N-[4-(Benzyloxy)-3-methoxybenzyl]-5-phenyl-N-[2-(2-pyridinyl)ethyl]pentanamide
N-(4-(benzyloxy)-3-methoxybenzyl)-5-phenyl-N-(2-(pyridin-2-yl)ethyl)pentanamide
MCP110

Biological Activity

[Description]:

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras
Signaling Pathways >> MAPK/ERK Pathway >> Raf

[Target]

Ras

RAF


[In Vitro]

MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1]. MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1]. MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].

[References]

[1]. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
686.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C33H36N2O3

[ Molecular Weight ]:
508.651

[ Flash Point ]:
368.8±31.5 °C

[ Exact Mass ]:
508.272583

[ LogP ]:
6.24

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.594

Related Compounds