m-PEG4-SH

Names

[ CAS No. ]:
52190-55-3

[ Name ]:
m-PEG4-SH

[Synonym ]:
3,6,9,12-Tetraoxatridecane-1-thiol
2,5,8,11-TETRAOXATRIDECANE-13-THIOL

Biological Activity

[Description]:

m-PEG4-SH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Density]:
1.035

[ Molecular Formula ]:
C₉H₂₀O₄S

[ Molecular Weight ]:
224.31800

[ Exact Mass ]:
224.10800

[ PSA ]:
75.72000

[ LogP ]:
0.61240

[ Storage condition ]:
2-8°C

m-PEG4-SH

Names

Biological Activity

Chemical & Physical Properties

Related Compounds